Leaders in Research

You may view the list of scholars arranged

alphabetically by class year

by institution by geography

by research topic

Todd E. Golde, MD, PhD Associate Professor and Chair Department of Neuroscience Mayo Clinic Jacksonville Todd E. Golde MD PhD, is an Associate Professor in the Department of Neuroscience at Mayo Clinic Jacksonville. His research over the past 12 years has focused on the role of the amyloid b protein (Ab) in Alzheimer’s disease (AD). During his training as an MD PhD student in the laboratory of Steve Younkin, Dr. Golde and colleagues showed that Ab was a normally derived product of the amyloid b protein precursor (APP), and later he played a major role in studies showing that mutant forms of the APP alter processing of the APP in manner that is likely to drive Ab aggregation and accumulation in the AD brain. After receiving his MD and PhD degrees from Case Western Reserve University, Dr. Golde completed a clinical residency in Laboratory Medicine at the University of Pennsylvania. After his residency Dr. Golde joined the Department of Pathology at the University of Pennsylvania as an assistant professor, and two years later joined the Neurodegenerative Research group in Mayo Clinic Jacksonville. His current research is focused on understanding the mechanism by which different Ab peptides are made, pursuing ways in which Ab metabolism can be pharmacologically manipulated, and trying to understand how Ab deposition leads to neuronal dysfunction and death. He hopes that the insights form these studies can translate into effective therapies for the treatment or prevention of AD.

Primary Research (for Beeson Program): Gamma-Secretases In Alzheimer’s Disease