Leaders in Research

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James R. Burke, MD, PHD Associate Professor of Medicine (Neurology); Director, Memory Disorders Clinic Associate Director, Bryan Alzheimer's Clinic Duke University Medical Center James R. Burke, M.D., Ph.D. is in the Division of Neurology at the Duke University School of Medicine. He received his undergraduate degree in Biology and English from Manhattan College. He graduated from the University of Tennessee- Oak Ridge National Laboratory Graduate School of Biomedical Sciences with a Ph.D. degree in Biochemistry. His thesis examined the effect of aging on the fidelity of protein synthesis. Dr. Burke attended medical school at the State University of New York Health Sciences Center in Brooklyn and received his M.D. degree in 1985. Following an internship in New York, Dr. Burke completed a neurology residency and Aging fellowship at Duke University. Dr. Burke remains on faculty at Duke and was named an Assistant Professor in 1993. His clinical practice consists primarily of patients with neurodegenerative disease. He is the Director of Clinical Research on Dementia at the Joseph and Kathleen Bryan Alzheimer's Disease Research Center. The goal of Dr. Burke's research is to understand the role of abnormal protein-protein interactions in the development of neurodegenerative disease. His laboratory studies polyglutamine as a model protein to characterize these interactions. He has received funding for this work from the Hereditary Disease Foundation, the Wills Foundation, a Clinical Investigator Development Award from the National Institute of Neurologic Disorders and Stroke and an RO1 from the NIH.

Primary Research (for Beeson Program): Peptide Inhibitors Of Pathologic Polyglutamine-Protein Interactions